Project Information

• Status: self-initiated project, not funded.

Most biological interactions are of the protein-protein type, and so are many mechanisms that once defective, lead to disease. Targeting Protein-Protein interactions (PPIs) by small-molecule modulators (PPIMs) is an attractive drug therapy strategy. Some PPIMs were already introduced into the clinic. However, blocking PPI is considered a more difficult task than inhibiting enzymes or antagonizing receptor activity, mainly due to the much larger interaction surfaces.

We examine if it is possible to characterize and classify PPIMs compared to other small molecules, and use PPIMs and small molecules in research associated with the need to block protein-protein interaction. Also, we examined and submitted a paper dealing with the question of specificity in PPIMs.